Glutamin for TPN

As respond to Lai Peng's post on TPN :

• Glutamine : as a cellular protective effect by converting to glutathione in cell (once uptaken). Glutathione will then exhibit antioxidant effect and prevent cellular and end-organ damage.

• Glutamine improve cellular hydration, improve anabolic effect

• Glutamine also improve immunological function by :

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↑ T-cell DNA Synthesis

↑ Lymphocyte Counts

↑ Macrophages Phargocytosi

↑ Rate to restore IgA to Normal

↑ Glutathione

↓ Infections rate ; ↑ Survival Rate

SUMMARY OF RESEARCH FINDINGS (click the table to view it clearer)

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Fan YP, Yu JC, Kang WM et al. Effects of glutamine supplementation on patients undergoing abdominal surgery. Chin Med Sci J. 2009; 24: 55-9.

-Jiang ZM, Jang H, Furst P. The impact of glutamine dipeptides on outcome of surgical patients: systematic review of randomized controlled trials from Europe and Asia. Clinc Nutrition Supp 2004; 1:17-23

-Zheng YM, Li F, Zhang MM, et al. Glutamine dipeptide for parenteral nutrition in abdominal surgery: A meta-analysis of randomized controlled trials. World J Gastroenterol 2006; 12: 7537-41

-Song JX, Tu XH, Li CJ. Glutamine dipeptide-supplemental parenteral nutrition in patients with colorectal cancer. Clin Nutr Supp 2004; 1: 49-53.

-Mertes N, Schulzki C, Goeters C, et al. Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study. Clinc Nutr 2000; 19: 395-401.

-Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine Supplementation in Cancer Patients Receiving Chemotherapy: A Double-blind Randomized Study. Nutrition 1997; 13: 748-51.