Wednesday, November 25, 2009

Glutamin for TPN

As respond to Lai Peng's post on TPN :
  • Glutamine : as a cellular protective effect by converting to glutathione in cell (once uptaken). Glutathione will then exhibit antioxidant effect and prevent cellular and end-organ damage.

  • Glutamine improve cellular hydration, improve anabolic effect
  • Glutamine also improve immunological function by :

  • ↑ T-cell DNA Synthesis
  • ↑ Lymphocyte Counts
  • ↑ Macrophages Phargocytosi
  • ↑ Rate to restore IgA to Normal
  • ↑ Glutathione

  • ↓ Infections rate ; ↑ Survival Rate

SUMMARY OF RESEARCH FINDINGS (click the table to view it clearer)

Fan YP, Yu JC, Kang WM et al. Effects of glutamine supplementation on patients undergoing abdominal surgery. Chin Med Sci J. 2009; 24: 55-9.

-Jiang ZM, Jang H, Furst P. The impact of glutamine dipeptides on outcome of surgical patients: systematic review of randomized controlled trials from Europe and Asia. Clinc Nutrition Supp 2004; 1:17-23

-Zheng YM, Li F, Zhang MM, et al. Glutamine dipeptide for parenteral nutrition in abdominal surgery: A meta-analysis of randomized controlled trials. World J Gastroenterol 2006; 12: 7537-41

-Song JX, Tu XH, Li CJ. Glutamine dipeptide-supplemental parenteral nutrition in patients with colorectal cancer. Clin Nutr Supp 2004; 1: 49-53.

-Mertes N, Schulzki C, Goeters C, et al. Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study. Clinc Nutr 2000; 19: 395-401.

-Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine Supplementation in Cancer Patients Receiving Chemotherapy: A Double-blind Randomized Study. Nutrition 1997; 13: 748-51.

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