TOPICS COVERED IN MECHANISM-BASED THERAPIES FOR HEART FAILURE AND CARDIAC ARRHYTHMIAS
Introduction to excitation-contraction coupling - History of the field of EC coupling - Introduction to the ryanodine receptor/calcium release channel (RyR2) - Mechanisms that regulate the RyR2 channel during stress - Defective regulation of RyR2 in heart failure - Evidence that diastolic sarcoplasmic reticulum (SR) calcium leak causes heart failure and arrhythmias in vivo - Novel therapeutic approaches to treating heart failure and preventing sudden cardiac death by fixing the leak in RyR2 channels
How to cite this talk:
Marks, A. (2007), "Mechanism-Based Therapies for Heart Failure and Cardiac Arrhythmias", in Simpson, A. (ed.),Calcium Signaling: Regulation, Mechanisms, Effectors, Role in Disease and Recent Advances, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://hstalks.com/bio)
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